Synthesis and characterization of pores bioactive glass nanomaterials for bone tissue engineering

Abstract

 Bioactive glass (BG) is one of the most remarkable biomaterials in the field of biomedical applications due to owing properties such as, bioactivity, biodegradability, biocompatibility and etc., which mainly used for the applications of bone implants, dermal fillers and drug releasing carriers. Bioactive glass materials which contain pores spherical structure are the most predominant materials in the field of biomedical applications due to owing its superior properties such as, large porosity, higher specific surface area and possible applications for bone implants, sealing materials in dentistry and drug releasing carriers. Here we report an easily controllable continuous method to produce pores spherical bioactive glasses (PSBGs) microspheres. We used poly (ethylene glycol) (PEG), to produce pores spherical bioactive glasses (PSBGs) with controlled internal morphology using a spray pyrolysis method. Surface morphologies and inner structures of all bioactive glass (BG) powders were examined by scanning electron microscopy and transmission electron microscopy, respectively. In addition, the in vitro bioactivity was examined by SEM after soaking in stimulated body fluid (SBF). The in vitro bioactivity of BG powders was determined by evaluating their apatite-forming ability in simulated body fluid (SBF). The results showed that PSBGs possessed the better hydroxyapatite-forming capacity than SBGs. Therefore, the PSBG’s have better in vitro bioactivity ability is critical for future tissue engineering development.