Synthesis and characterization of pores bioactive glass nanomaterial for bone tissue engineering

Abstract

Bioactive glass (BG) is among the most remarkable biomaterials inbiomedical applications owing to properties including bioactivity, biodegradability, and biocompatibility. It is basically applied for bone implants, dermal fillers, and drug-releasing carriers. Bioactive glass materials containing pores with a spherical structure are the most predominant in biomedical applications due to superior properties such as large porosity, higher specific surface area, and potential applications for bone implants, sealing materials in dentistry, and drug-releasing carriers. Here, it is reported that an easily controllable continuous method to yield porous spherical bioactive glasses (PSBGs) microspheres. Poly (ethylene glycol) (PEG) was used to produce porous spherical bioactive glasses (PSBGs) with controlled internal morphology using a spray pyrolysis method. Surface morphologies and inner structures of all bioactive glass (BG) powders were investigated by scanning electron microscopy and transmission electron microscopy, respectively. Besides, the in vitro bioactivity was assessed by SEM after soaking in simulated body fluid (SBF). The in vitro bioactivity of BG powders was determined by evaluating their apatite-forming ability in simulated body fluid (SBF). The results indicated that PSBGs possessed better hydroxyapatite-forming capacity than SBGs. Hence, the better in vitro bioactivity of PSBGs is vital for future tissue engineering improvement.